Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States

Figure 2

Part of the inflammasome network model scored with transcriptomic data from GSE55235. The bar graph above each node, which was scored, shows the inferred fold change in the synovial tissues of (1) osteoarthritis (OA) and (2) rheumatoid arthritis (RA) patients relative to healthy subjects. The directionalities are shown as yellow or blue bars for inferred upregulation or downregulation, respectively. The black outline refers to nodes that were significantly impacted in both diseases, the blue outline refers to nodes that were significantly impacted only in OA, and the purple outline refers to nodes that were significantly impacted only in RA.