Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States

Figure 5

Part of the inflammasome network model scored with transcriptomic data from GSE11258. The bar graph above each node, which was scored, shows the inferred fold change in mouse hippocampus after (1) 1 hour, (2) 3 hours, and (3) 6 hours of 50 mM KCl treatment. The directionalities are shown as yellow or blue bars for inferred upregulation or downregulation, respectively. The black outline refers to nodes that were significantly impacted at all time points, and the purple outline refers to nodes that were significantly impacted at two time points.