International Journal of Inflammation

Adaptive immunity and inflammation


Publishing date
07 Nov 2014
Status
Published
Submission deadline
20 Jun 2014

1Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy

2Department of Science, University of Basilicata, Via Ateneo Lucano, 85100 Potenza, Italy

3Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK

4Cellular Immunology, Biomedical Research Foundation Academy of Athens, Athens, Greece


Adaptive immunity and inflammation

Description

Inflammation is part of a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants.

Local signals at the sites of inflammation mediate rapid cells mobilization and recruitment and dictate differentiation programs whereby these cells drive clearance of “inflammatory inducers” and promote resolution and restoration of tissue homeostasis. However, persistent inflammatory stimuli or dysregulation of mechanisms of the resolution phase can lead to chronic inflammation.

This phenomenon, from a “temporal point of view,” distinguishes a first cellular subset that responds to proinflammatory stimuli, commonly referred to as innate immunity (PMN leukocytes), later followed by cellular components, classically catalogued as adaptive immunity.

From this point of view, inflammation is a stereotyped response, and therefore, it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen.

Intriguingly, it is now emerging the hypothesis that components of adaptive immunity play a crucial role in both the acute and chronic phases of the inflammatory process. This “novel view” supports even more the evidence that lymphocytes cooperate with innate immunity cells and together orchestrate the whole inflammatory response.

We invite investigators to submit original research and review articles that will stimulate the continuing efforts to understand the interaction between the adaptive immunity and the inflammatory process in humans and also in animal models. Potential topics include, but are not limited to:

  • Elucidation of the role/mechanism in lymphocytes involvement during acute and/or chronic inflammation
  • Identification of new T cell subsets as functional regulators of immune and nonimmune cells
  • New insights in modulation of inflammation by immune cells
  • Development of novel anti-inflammatory molecules and immunotherapeutic strategies to treat inflammation
  • New cellular and animal models to test and understand the inflammatory process

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/iji/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/iji/aii/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 575406
  • - Editorial

Adaptive Immunity and Inflammation

Brancaleone Vincenzo | Iqbal J. Asif | ... | Maione Francesco
  • Special Issue
  • - Volume 2014
  • - Article ID 878054
  • - Research Article

Live Combined Bacillus subtilis and Enterococcus faecium Ameliorate Murine Experimental Colitis by Immunosuppression

S. Chen | Y. Fu | ... | K. F. Zou
  • Special Issue
  • - Volume 2014
  • - Article ID 814760
  • - Review Article

Contradictory Immune Response in Post Liver Transplantation Hepatitis B and C

Akinobu Takaki | Takahito Yagi | Kazuhide Yamamoto
  • Special Issue
  • - Volume 2014
  • - Article ID 248240
  • - Research Article

Neurotensin Decreases the Proinflammatory Status of Human Skin Fibroblasts and Increases Epidermal Growth Factor Expression

Lucília Pereira da Silva | Bruno Miguel Neves | ... | Eugénia Carvalho
  • Special Issue
  • - Volume 2014
  • - Article ID 651503
  • - Review Article

Th17 Cells in Autoimmune and Infectious Diseases

José Francisco Zambrano-Zaragoza | Enrique Jhonatan Romo-Martínez | ... | Norberto Vibanco-Pérez
  • Special Issue
  • - Volume 2014
  • - Article ID 149628
  • - Research Article

Limited Applicability of GW9662 to Elucidate PPARγ-Mediated Fatty Acid Effects in Primary Human T-Helper Cells

Anke Jaudszus | Stefan Lorkowski | ... | Gerhard Jahreis
  • Special Issue
  • - Volume 2014
  • - Article ID 247503
  • - Research Article

Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery

Francesco Maione | Antonio Parisi | ... | Carla Cicala
International Journal of Inflammation
 Journal metrics
Acceptance rate13%
Submission to final decision64 days
Acceptance to publication36 days
CiteScore5.500
Impact Factor-
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