Epithelial Cell Gene Expression Induced by Intracellular Staphylococcus aureus

Table 2

Microarray analysis of gene expression changes in infected HEp-2 cell monolayers.

Category	Gene	Fold change (P value)
		2 h	4 h	6 h	8 h
Stress response	atf3	7.89 (.024)	1.53 (.113)	2.00 (.041)	0.85 (.189)
	c-fos	2.59 (.052)	1.21 (.072)	0.911 (.302)	0.843 (.287)
	fosB	2.29 (.009)	1.14 (.605)	0.95 (.919)	1.10 (.101)
	c-jun	1.88 (.011)	1.40 (.094)	0.77 (.064)	1.27 (.035)
	junB	1.98 (.007)	1.16 (.015)	1.22 (.015)	1.03 (.407)
	sgk	4.17 (.018)	2.16 (.005)	1.84 (.178)	2.13 (.066)
Signal transduction	map2k1	1.23 (.835)	1.52 (.025)	1.80 (.030)	2.86 (.041)
	arhe	2.61 (.005)	2.31 (.060)	1.26 (.370)	1.70 (.085)
	arhb	2.21 (.044)	2.18 (.004)	1.78 (.065)	1.60 (.022)
	ack-1	0.67 (.061)	0.56 (.081)	0.39 (.004)	0.51 (.026)
	map2k3	1.98 (.014)	2.41 (.003)	1.96 (.127)	2.33 (.052)
Proinflammatory response	cox2	3.32 (.012)	2.71 (.088)	1.29 (.065)	2.55 (.064)
Cell proliferation and proapoptosis	dkk1	2.17 (.026)	7.11 (.001)	3.23 (.012)	4.52 (.055)
	klf4	2.33 (.001)	1.78 (.134)	1.61 (.008)	1.61 (.104)
	klf6	2.51 (.019)	1.50 (.064)	1.52 (.046)	1.62 (.090)
	Igfbp1	2.54 (.062)	4.32 (.001)	2.13 (.086)	11.10 (.030)
	Igfbp3	0.77 (.664)	1.80 (.051)	3.65 (.003)	2.23 (.088)
	casp9	1.95 (.015)	1.57 (.021)	0.54 (.617)	0.78 (.666)
	bnip3	1.25 (.073)	1.64 (.034)	2.86 (.002)	2.47 (.041)
	nur77	6.17 (.038)	1.28 (.181)	0.78 (.114)	0.87 (.235)
Profibrotic	tgfbr2	1.47 (.011)	1.67 (.083)	2.09 (.008)	2.10 (.010)
	v-erb-b	0.96 (.608)	1.67 (.055)	1.96 (.005)	2.11 (.007)
	itga5	0.88 (.768)	2.19 (.037)	2.12 (.033)	3.20 (.030)
	thbs1	1.28 (.112)	2.93 (.001)	2.54 (.024)	2.44 (.209)
	pai1	2.45 (.006)	1.80 (.040)	1.27 (.089)	1.32 (.136)
	pai2	ND	2.09 (.015)	4.43 (.001)	4.13 (.013)
	cyr61	4.43 (.007)	3.24 (.001)	2.33 (.152)	1.61 (.249)
	ctgf	6.78 (.026)	2.13 (.141)	ND	ND
	nov	1.46 (.301)	1.98 (.059)	2.05 (.002)	2.15 (.006)
Cholesterol synthesis	sc4mol	0.81 (.367)	0.32 (.001)	0.36 (.001)	0.31 (.001)
	hmgcr	1.11 (.700)	0.30 (.002)	0.21 (.001)	0.36 (.016)
	hsd17b7	0.74 (.189)	0.50 (.001)	0.30 (.006)	0.31 (.014)
	idi1	1.00 (.979)	0.53 (.018)	0.33 (.004)	0.31 (.151)
	sqle	0.90 (.397)	0.50 (.007)	0.26 (.001)	0.31 (.008)
	sc5dl	0.90 (.358)	0.45 (.017)	0.23 (.008)	0.35 (.064)
	fdft1	0.96 (.551)	0.59 (.002)	0.29 (.001)	0.26 (.010)
	dhcr7	0.95 (.527)	0.63 (.010)	0.51 (.016)	0.39 (.014)
	insig1	0.69 (.338)	0.20 (.001)	0.26 (.001)	0.41 (.014)
	acas2	ND	0.58 (.080)	0.27 (.001)	0.37 (.024)
	ldlr	1.09 (.048)	0.41 (.002)	0.54 (.017)	0.68 (.114)

ND: Not determined. Data not shown due to low signal intensity (<50).