The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line TB Drugs Reveals Stress- and PE/PPE-Related Drug Targets

Table 1

Genes differentially induced in response to capreomycin and PA-824 relative to other drugs.

ORF	Gene	Product/Function	Score	𝑞-value %
Rv2657c	—	Probable phirv2 prophage protein	4.73	0
Rv2374c	hrcA	Probable heat shock protein transcriptional repressor	4.12	0
Rv0354c	PPE7	PPE family protein	3.80	0
Rv1364c	—	Conserved hypothetical protein	3.54	0
Rv2304c	—	Hypothetical protein	3.52	0
Rv0367c	—	Hypothetical protein	3.30	0
Rv0607	—	Hypothetical protein	3.26	0
Rv2466c	—	Conserved hypothetical protein	3.21	0
Rv0830	—	Conserved hypothetical protein	3.18	0
Rv2557	—	Conserved hypothetical protein	3.16	0
Rv2142c	—	Hypothetical protein	3.02	0
Rv0654	—	Probable dioxygenase	2.99	0
Rv1977	—	Conserved hypothetical protein	2.99	0
Rv2688c	—	Probable antibiotic-transport ATP-binding protein	2.98	0
Rv1285	cysD	Probable sulfate adenylyltransferase subunit 2	2.82	1.04
Rv0047c	—	Conserved hypothetical protein	2.77	1.73
Rv2878c	mpt53	Soluble secreted antigen mpt53 precursor	2.74	1.73
Rv2254c	—	Probable integral membrane protein	2.63	1.86
Rv1986	—	Probable conserved integral membrane protein	2.60	1.86
Rv2777c	—	Conserved hypothetical protein	2.60	1.86
Rv2413c	—	Conserved hypothetical protein	2.59	1.86
Rv1929c	—	Conserved hypothetical protein	2.59	1.86
Rv3288c	usfY	Putative protein	2.57	1.86
Rv2535c	PEPQ	Probable cytoplasmic peptidase	2.54	2.27
Rv2634c	PE_PGRS46	PE_PGRS family protein	2.54	2.27
Rv1646	PE17	PE family protein	2.49	2.72
Rv2749	—	Conserved hypothetical protein	2.46	2.72
Rv3452	cut4	Probable cutinase precursor cut4	2.44	3.22
Rv0192	—	Conserved hypothetical protein	2.41	3.22
Rv1687c	—	Probable conserved ATP-binding protein ABC transporter	2.41	3.22
Rv1087	PE_PGRS21	PE_PGRS family protein	2.37	4.35
Rv1566c	—	Possible inv protein	2.36	4.35
Rv2504c	scoA	Probable succinyl-coa3-ketoacid-coenzyme A transferase	2.35	4.35
Rv0834c	PE_PGRS14	PE_PGRS family protein	2.33	4.35
Rv0274	—	Conserved hypothetical protein	2.33	4.35
Rv2162c	PE_PGRS38	PE_PGRS family protein	2.30	4.35
Rv0365c	—	Conserved hypothetical protein	2.30	4.35
Rv3550	echA20	Probable enoyl-CoA hydratase	2.27	4.67
Rv3367	PE_PGRS51	PE_PGRS family protein	2.26	4.67
Rv2802c	—	Hypothetical arginine and alanine rich protein	2.25	4.67
Rv2291	sseB	Probable thiosulfate sulfurtransferase	2.25	4.67
Rv3189	—	Conserved hypothetical protein	2.25	4.67

*Score: the 𝑡-statistic score. 𝑞-value: the level of significance based on SAM.