Research Article
Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains
Table 1
Main characteristics of the isolates and results of relative quantification of resistance genes for French VL patients. NA: nonamplified.
| Patients | Parasite identification | Site/time of isolation | PGP | MDR | GSH | DHFR | PTR1 |
| F1 | L. infantum MON 24 | blood j 0 | 1.12 | 3.22 | 0.85 | 0.94 | 0.91 | L. infantum MON 24 | blood j 30 | 0.78 | 2.83 | 0.79 | 0.67 | 0.96 | L. infantum MON 24 | bone marrow j130 | 0.94 | 4.17 | 0.75 | 0.48 | 0.96 |
| F2 | L. infantum MON 24 | blood j 0 | 3.07 | 6.1 | 0.93 | 1.04 | 1.05 | L. infantum MON 24 | peau j10 | 3.64 | 4.86 | 0.88 | 0.97 | 0.91 |
| F3 | L. infantum MON 33 | blood j 0 | 1.3 | 4.05 | 0.95 | 0.75 | 1.02 | L. infantum MON 33 | blood j 90 | 1.67 | 3.87 | 0.94 | 0.66 | 1.03 | L. infantum MON 33 | blood j 250 | 1.18 | 5.41 | 0.88 | 0.6 | 0.99 | L. infantum MON 33 | blood j 540 | 0.94 | 4.83 | 0.86 | 0.81 | 0.98 | L. infantum MON 33 | blood j 1020 | 1.6 | 4.4 | 0.78 | 0.75 | 0.86 | L. infantum MON 33 | blood j 1440 | 1.32 | 3.67 | 0.73 | 0.83 | 0.84 | L. infantum MON 33 | blood j 1830 | 1.01 | 4.82 | 0.73 | 0.73 | 0.93 |
| F4 | L. infantum MON 1 | blood j 0 | 1.2 | 5.52 | 0.97 | 15.59 | 0.74 | L. infantum MON 1 | blood j 100 | 1.21 | 6.26 | 1.01 | 16.2 | 0.73 |
| F5 | L. infantum MON 1 | cavum j 0 | 1.78 | 3.01 | 1.01 | 1.48 | 1.05 | L. infantum MON 1 | blood j 90 | 1.91 | 3.97 | 0.94 | 1.31 | 1.07 | L. infantum MON 1 | blood j 180 | 1.57 | 3.44 | 0.71 | 0.87 | 1.11 | L. infantum MON 1 | skin j 180 | 2.13 | 4.3 | 0.65 | 0.89 | 0.94 |
| F6 | L. infantum MON 1 | blood j 0 | 1.53 | 12 | 1.25 | 11.5 | 1.11 | L. infantum MON 1 | blood j 450 | 1.19 | 8.72 | 1.28 | 19.1 | 1.17 | L. infantum MON 1 | blood j 810 | 1.29 | 8.4 | 1.64 | 12.8 | 1.12 |
| F7 | L. infantum MON 24 | bone marrow j 0 | 1.12 | 3.94 | 0.86 | 0.71 | 0.85 | L. infantum MON 24 | bone marrow j 30 | 1.13 | 3.97 | 0.83 | 0.62 | 0.77 |
| F8 | L. infantum MON 1 | blood j 0 | 1.02 | 4.06 | 1.05 | 7.39 | 1.11 | L. infantum MON 1 | bone marrow j 15 | 1.11 | 3.02 | 1.08 | 10.7 | 1.08 | L. infantum MON 1 | blood j 660 | 1.82 | 2.68 | 0.97 | 5.71 | 0.96 | L. infantum MON 1 | blood j 720 | 7.84 | 2.8 | 0.85 | 5.03 | 0.91 | L. infantum MON 1 | blood j 850 | 7.49 | 3.73 | 0.85 | 5.09 | 0.93 |
| F9 | L. infantum MON 24 | blood j 0 | 1.02 | 5.32 | 1 | 16.05 | 0.66 | L. infantum MON 24 | blood j 10 | 0.88 | 4.61 | 0.8 | 16.8 | 0.67 | L. infantum MON 24 | blood j 110 | 0.96 | 7.88 | 1.02 | 15.1 | 0.69 | L. infantum MON 24 | blood j 390 | 0.94 | 7.4 | 0.67 | 9.98 | 0.64 | L. infantum MON 24 | blood j 1140 | 0.98 | 8.67 | 1.42 | 5.89 | 0.66 | L. infantum MON 24 | blood j 1240 | 0.95 | 6.68 | 1.3 | 11.7 | 0.68 |
| F10 | L. infantum MON 24 | blood j 0 | 1.1 | 5.05 | 0.72 | 0.83 | 0.74 | L. infantum MON 24 | blood j 15 | 0.62 | 4.01 | 0.58 | 0.81 | 0.71 | L. infantum MON 24 | blood j 50 | 1.2 | 4.19 | 0.81 | 0.85 | 0.65 | L. infantum MON 24 | blood j 80 | 1.13 | 3.67 | 0.65 | 0.96 | 0.67 | L. infantum MON 24 | blood j 420 | 0.99 | 5.48 | 0.63 | 0.91 | 0.71 |
| F11 | L. infantum MON 1 | bone marrow j 0 | 1.47 | 5.32 | 0.67 | 0.92 | 0.73 | L. infantum MON 1 | bone marrow j 110 | 1.67 | 4.56 | 0.6 | 0.61 | 0.79 |
| F12 | L. infantum MON 1 | bone marrow j 0 | 1.65 | 4.04 | 0.83 | 0.85 | NA | L. infantum MON 1 | bone marrow j360 | 1.78 | 6.75 | 0.75 | 0.76 | NA | L. infantum MON 1 | blood j 810 | 2.58 | 4.22 | 0.66 | 0.67 | NA | L. infantum MON 1 | blood j 1800 | 2.07 | 4.58 | 0.85 | 0.67 | NA |
| F13 | L. infantum MON 24 | bone marrow j 0 | 0.71 | 1.66 | 0.74 | 2.49 | 0.86 | L. infantum MON 24 | skin j 4 | 1.28 | 2.17 | 0.81 | 1.19 | 0.81 | L. infantum MON 24 | blood j 810 | 0.82 | 1.77 | 0.74 | 1.36 | 0.82 | F14 | L. infantum MON 24 | blood j 0 | 0.76 | 5.22 | 0.87 | 0.69 | 0.8 | L. infantum MON 24 | blood j 10 | 0.78 | 4.9 | 0.75 | 0.56 | 0.82 | L. infantum MON 24 | blood j 165 | 0.95 | 4.89 | 0.61 | 0.73 | 0.84 | L. infantum MON 24 | blood j 420 | 0.98 | 5.61 | 0.59 | 0.87 | 0.78 | L. infantum MON 24 | blood j 630 | 0.66 | 4.56 | 0.63 | 1 | 0.75 |
| F15 | L. infantum MON 24 | blood j 0 | 1 | 3.42 | 1.31 | 0.61 | 1 | L. infantum MON 24 | blood j 240 | 0.89 | 3.97 | 0.69 | 0.73 | 0.93 | L. infantum MON 24 | blood j 400 | 0.73 | 4.07 | 0.68 | 0.59 | 0.96 | L. infantum MON 24 | blood j 580 | 1.48 | 5.09 | 0.64 | 0.8 | 0.95 |
| F16 | L. infantum MON 1 | bone marrow j 0 | 0.86 | 3.68 | 0.82 | 1.53 | 0.91 | L. infantum MON 1 | skin j 710 | 0.82 | 3.05 | 0.52 | 2.05 | 0.92 | L. infantum MON 1 | blood j 1700 | 0.92 | 4.31 | 0.51 | 2.21 | 0.81 |
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