Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

Table 5

Distribution of the isolates displaying amplified genes according to the Leishmania species. ∗Amplification observed only with L. infantum.

Species	PGP A	MDR 1	GSH	DHFR∗	PTR
𝑁 (%) of amplified genes	44	45	44	42	33
L. archibaldi (𝑛=6)	0 (0.0)	4 (66.7)	0 (0.0)	0 (0.0)	0 (0.0)
L. donovani (𝑛=17)	3 (20.0)	7 (43.8)	2 (13.3)	0 (0.0)	3 (21.4)
L. infantum (𝑛=23)	2 (8.7)	19 (82.6)	1 (4.4)	5 (21.7)	0 (0.0)
Total	5 (11.4)	30 (66.7)	3 (6.8)	5 (11.9)	3 (9.1)
	𝑃=.36	𝑃=.04	𝑃=.44	𝑃=.10	𝑃=.11