Research Article

Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

Figure 1

Regulation of MalT and its regulon. malT transcription is activated by the global regulator CRP-cAMP and repressed by Mlc. Translation of MalT is activated by H-NS and StpA. Activation of MalT activity can be attained by the binding of maltotriose, whereas it is inhibited by interaction with MalK, MalY, Aes, or glucokinase. Upon activation, MalT positively regulates expression of proteins that facilitate maltose uptake and metabolism.
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