Pseudomonas sp. as a Source of Medium Chain Length Polyhydroxyalkanoates for Controlled Drug Delivery: Perspective

Table 1

Classes of PHA synthases and varieties of P (3HA)s (adapted from Rehm 2007) [10].

Substrate specificity	Class of PHA synthase	Subunit(s); (PHA synthase subunit)	Microorganism	Polymers produced^a
SCL-3HA-CoA (C3–C5)	I	PhaC	Ralstonia eutropha	P (3HB), P (3HB-co-3HV)
	III	PhaC, PhaE	Allochromatium
	IV	PhaC,PhaR	vinosum; Bacillus megaterium
MCL-3HA-CoA (C6–C14)	II	PhaC	Pseudomonas	P (3HA)
			oleovorans
			Pseudomonas putida
			Pseudomonas aeruginosa
SCL-MCL-	I	PhaC	Aeromonas caviae	P (3HB-co-3HA)
P (3HA)-CoA (C3–C14)	II	PhaC	FA440
			Pseudomonas sp.61-3

^aP (3HB), poly-3-hydroxybutyrate, P (3HB-co-3HV), poly-3-hydroxybutyrate-co-3-hydroxyvalerate, P (3HA), poly-3-hydroxyalkanoate, P (3HB-co-3HA), poly-3-hydroxybutyrate-co-3-hydroxyalkanoate.