Review Article

Development of Class IIa Bacteriocins as Therapeutic Agents

Table 1

Fusion partners used for class IIa bacteriocins.

Fusion partnerBacteriocin

ThioredoxinPediocin PA-1 [95, 98], carnobacteriocins BM1 and B2 [50], divercin V41 [96], enterocin P [72], piscicolin 126 [99]

Maltose-binding proteinCarnobacteriocin B2 [93] and its precursor [22], Pediocin AcH [100]

Intein-chitin-binding domainPiscicolin 126, divercin V41, enterocin P, pediocin PA-1 [101]

Dihydrofolate reductasePediocin PA-1 [94]

Xpress tagPediocin PA-1 [102]

Cellulose-binding domainEnterocin A [103]

Hexahistidine tagPediocin PA-1 [104]