Table of Contents Author Guidelines Submit a Manuscript
International Journal of Microbiology
Volume 2012, Article ID 575193, 3 pages
http://dx.doi.org/10.1155/2012/575193
Research Article

Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa

1Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam 693917134, Iran
2Department of Microbiology, Qom Branch, Islamic Azad University of Qom, Qom, Iran

Received 10 January 2012; Revised 17 February 2012; Accepted 17 February 2012

Academic Editor: Todd R. Callaway

Copyright © 2012 Nourkhoda Sadeghifard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. E. W. Hancock and D. P. Speert, “Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment,” Drug Resistance Updates, vol. 3, no. 4, pp. 247–255, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. D. S. Blanc, C. Petignat, B. Janin, J. Bille, and P. Francioli, “Frequency and molecular diversity of Pseudomonas aeruginosa upon admission and during hospitalization: a prospective epidemiologic study,” Clinical Microbiology and Infection, vol. 4, no. 5, pp. 242–247, 1998. View at Google Scholar · View at Scopus
  3. K. Bush, G. A. Jacoby, and A. A. Medeiros, “A functional classification scheme for β-lactamases and its correlation with molecular structure,” Antimicrobial Agents and Chemotherapy, vol. 39, no. 6, pp. 1211–1233, 1995. View at Google Scholar · View at Scopus
  4. F. Bert, Z. Ould-Hocine, M. Juvin et al., “Evaluation of the Osiris expert system for identification of β-lactam phenotypes in isolates of Pseudomonas aeruginosa,” Journal of Clinical Microbiology, vol. 41, no. 8, pp. 3712–3718, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. D. M. Livermore, “Penicillin-binding proteins, porins and outer-membrane permeability of carbenicillin-resistant and -susceptible strains of Pseudomonas aeruginosa,” Journal of Medical Microbiology, vol. 18, no. 2, pp. 261–270, 1984. View at Google Scholar · View at Scopus
  6. D. M. Livermore, “Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?” Clinical Infectious Diseases, vol. 34, no. 5, pp. 634–640, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Srikumar, C. J. Paul, and K. Poole, “Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa,” Journal of Bacteriology, vol. 182, no. 5, pp. 1410–1414, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Cao, R. Srikumar, and K. Poole, “MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719,” Molecular Microbiology, vol. 53, no. 5, pp. 1423–1436, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Bisbe, J. M. Gatell, J. Puig et al., “Pseudomonas aeruginosa bacteremia: univariate and multivariate analyses of factors influencing the prognosis in 133 episodes,” Reviews of Infectious Diseases, vol. 10, no. 3, pp. 629–635, 1988. View at Google Scholar · View at Scopus
  10. V. Aloush, S. Navon-Venezia, Y. Seigman-Igra, S. Cabili, and Y. Carmeli, “Multidrug-resistant Pseudomonas aeruginosa: risk factors and clinical impact,” Antimicrobial Agents and Chemotherapy, vol. 50, no. 1, pp. 43–48, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Saito, H. Yoneyama, and T. Nakae, “NalB-type mutations causing the overexpression of the MexA-MexB-OprM efflux pump are located in the mexR gene of the Pseudomonas aeruginosa chromosome,” FEMS Microbiology Letters, vol. 179, no. 1, pp. 67–72, 1999. View at Publisher · View at Google Scholar