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International Journal of Microbiology
Volume 2012 (2012), Article ID 626745, 10 pages
Review Article

Experimental Models of Cryptococcosis

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Received 19 July 2011; Accepted 4 August 2011

Academic Editor: Julian R. Naglik

Copyright © 2012 Wilber Sabiiti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction. Here we review the range of experimental models that are available for cryptococcosis research and compare the relative advantages and limitations of the different systems.