Differential Adaptations of Methicillin-Resistant Staphylococcus aureus to Serial In Vitro Passage in Daptomycin: Evolution of Daptomycin Resistance and Role of Membrane Carotenoid Content and Fluidity

Table 4

Quantification of CM carotenoid pigment, CM fluidity and CW thickness.

Strains	Carotenoids (OD450)	CM fluidity (PI-value)	CW thickness (nm)
CB1118	0.49±0.003	0.279±0.0255	26.42±3.9
CB2206	0.50±0.032	0.321±0.0285^*	25.53±3.1
CB2207	0.63±0.099	0.304±0.0165	28.91±3.2^**
CB2208	0.67±0.054^*	0.365±0.0398^*	32.05±4.4^**
CB2209	0.65±0.064^*	0.357±0.0407^*	33.94±4.2^**
CB2210	0.75±0.014^*	0.392±0.0552^*	42.24±6.2^**

^*P value < 0.05 versus parental strain; ^**P value < 0.0001 versus parental strain.
A lower PI value equates to a greater extent of CM fluidity.