Table of Contents Author Guidelines Submit a Manuscript
International Journal of Microbiology
Volume 2012 (2012), Article ID 713687, 26 pages
Review Article

Antifungal Resistance and New Strategies to Control Fungal Infections

Institute of Microbiology, University of Lausanne and University Hospital, Rue du Bugnon 48, 1011 Lausanne, Switzerland

Received 21 July 2011; Accepted 6 September 2011

Academic Editor: Arianna Tavanti

Copyright © 2012 Patrick Vandeputte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.