The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide

Table 2

The MICs, MHCs, and therapeutic indices of the designed peptides.

Peptide	MIC (μg/mL)	MHC (μg/mL)	Therapeutic index	Hydrophobicity	Hydrophobic moment	%Helix	Net charge
P18	25	250	10	0.486	0.405	N	7
CP-P	12.5	250	20	0.411	0.648	63.2	7
S16	3.125	>500	160	0.323	0.596	71.8	7
F2	12.5	250	20	0.3	0.574	N	7
N3	12.5	N	N	0.343	0.599	72.5	6
K6	12.5	N	N	0.184	0.471	N	8
N7	12.5	>500	40	0.343	0.586	72.1	6
K9	>50	N	N	0.189	0.495	51.5	8
S9	50	>500	10	0.236	0.529	68.2	7
R9	>50	N	N	0.188	0.494	N	8
A9	25	>500	20	0.254	0.496	64.6	7
L10	12.5	<125	10	0.395	0.632	72.1	7
A10	12.5	250	20	0.326	0.597	72.5	7
D11	25	>500	20	0.287	0.631	71.6	6
K11	1.6	>500	320	0.276	0.642	67.4	8
L11	>50	N	N	0.411	0.513	N	7
A13	6.25	>500	80	0.249	0.522	45.9	7
K13	>50	N	N	0.184	0.457	62.6	8
K17	12.5	>500	40	0.258	0.551	58.7	8
D18	25	>500	20	0.343	0.587	51.4	5
N18	6.25	>500	80	0.343	0.58	37.2	6
N20	6.25	>500	80	0.204	0.483	N	7

Note: “N” signifies that the data were not determined.