Association of Transferable Quinolone Resistance Determinant qnrB19 with Extended-Spectrum β-Lactamases in Salmonella Give and Salmonella Heidelberg in Venezuela

Table 1

Antibiotic susceptibility of qnrB positive and ESBL-producing S. Give and S. Heidelberg isolates and their transformants, recipient E. coli HB101, and quality control E. coli ATCC 25922.

Antibiotics tested	MIC (mg/liter) for
	S. Give		E. coli transformants		S. Heidelberg		E. coli transformants		E. coli
	SG9611	SG9811	9611trf	9811trf	SH7511	SH7911	7511trf	7911trf	HB101	ATCC 25922
Cefoxitin	8	8	4	8	8	8	8	8	2	2
Cefotaxime	4	128	8	128	>256	>256	256	128	0.064	0.125
CTX/CLA	0.125	0.25	0.25	0.25	1	0.5	0.25	0.25	0.125	0.125
Ceftazidime	64	32	64	32	32	32	32	32	0.25	0.125
CAZ/CLA	0.25	0.125	0.25	0.25	0.25	0.25	0.125	0.125	0.25	0.125
Aztreonam	16	16	16	32	16	16	16	16	0.25	0.25
Ertapenem	0.064	0.064	0.064	0.064	0.064	0.064	0.032	0.064	0.064	0.032
Imipenem	0.064	0.064	0.064	0.064	0.064	0.064	0.064	0.064	0.032	0.032
Meropenem	0.064	0.032	0.064	0.064	0.064	0.064	0.064	0.064	0.032	0.032
Ciprofloxacin	1	1	1	1	1	1	1	2	0.125	0.015
Nalidixic Acid	8	4	8	4	4	8	4	8	2	1
Amikacin	4	2	2	2	8	2	8	8	0.25	0.25
Gentamicin	4	32	2	32	8	>64	16	64	0.5	1
Tobramycin	16	4	16	2	4	8	2	4	0.5	0.25
Other test DDST	+	+	+	+	+	+	+	+	−	−

CTX/CLA: cefotaxime/clavulanic acid; CAZ/CLA: ceftazidime/clavulanic acid; DDST: double disk synergy test.