Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans
Table 4
Human and C. albicans homologous proteins involved in GPI glycosylation.
Protein function
Protein H/Ca
Human ID*
Candida ID*
Id**
Cov***
GlcNAc-PI synthesis
PIG-A/Gpi3
NP_002632.1
XP_717439.1
49%
94%
PIG-C/Gpi2
NP_714969.1
XP_717493.1
31%
90%
PIG-H/Gpi15
NP_004560.1
XP_718197.1
33%
44%
PIG-P/Gpi19
NP_710149.1
XP_714916.1
33%
37%
PIG-Q/Gpi1
NP_683721.1
XP_714683.1
30%
42%
PIG-Y/Eri1
NP_001036081.1
XP_715355.1
64%
9%
GlcNAc-PI de-N-acetylation
PIG-L/Gpi12
NP_004269.1
XP_723585.1
29%
55%
Inositol acylation
PIG-W/Gwt1
NP_848612.2
XP_712842.1
28%
99%
1,6-mannosyltransferase
PIG-M/Gpi14
NP_660150.1
XP_722653.1
38%
94%
1,6-mannosyltransferase
PIG-X/Pbn1
NP_001159776.1
XP_716695.1
19%
24%
Etn-P transfer to Man-1
PIG-N/Mcd4
NP_789744.1
XP_716313.1
37%
95%
1,6-mannosyltransferase
PIG-V/Gpi18
NP_060307.2
XP_713712.1
24%
82%
1,2-mannosyltransferase
PIG-B/Gpi10
NP_004846.4
XP_721904.1
31%
97%
Etn-P transfer to Man-3
PIG-O/Gpi13
NP_001188413.1
XP_720956.1
38%
53%
Etn-P transfer to Man-2 and 3
PIG-F/Gpi11
NP_002634.1
XP_720511
35%
44%
Etn-P transfer to Man-2
PIG-G/Gpi7
NP_001120650.1
XP_710743.1
38%
47%
1,2-mannosyltransferase
Smp3
NP_079439.2
XP_715333.1
26%
91%
Etn-P transfer to Man-2
Gpi7
NP_001120650.1
EEQ42670.1
40%
72%
GPI transamidase
PIG-K/Gpi8
NP_005473.1
XP_711741.1
56%
78%
GAA1
NP_003792.1
XP_710522.1
35%
49%
PIG-S/Gpi17
NP_149975.1
XP_716135.1
27%
48%
PIG-T/Gpi16
NP_057021.2
XP_720200.1
29%
94%
PIG-U/Cdc91
NP_536724.1
XP_720773.1
24%
92%
Inositol deacylation
PGAP-1/Bst1
NP_079265.2
XP_713657.1
31%
75%
sn-2 deacylation
PGAP3/Per1
NP_219487.3
XP_712020.1
26%
95%
sn-2 acylation
PGAP2/Cwh43
NP_001269969.1
XP_717850.1
Accession number at NCBI database. Identity and coverage from BLAST alignment between human and C. albicans homologous sequences, respectively.
We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.
