Global Phenotypic Characterization of Effects of Fluoroquinolone Resistance Selection on the Metabolic Activities and Drug Susceptibilities of Clostridium perfringens Strains

Figure 1

Comparison of growth of fluoroquinolone-resistant mutants of NCTR and 3626 with the growth of the wild types in the presence of three dipeptides. W, NR, CR, and GR refer to wild type, norfloxacin-resistant, ciprofloxacin-resistant, and gatifloxacin-resistant, respectively. Statistically significant differences were observed in the growth of strains (). C indicates the dipeptide concentration equivalent to the proprietary concentration of the compounds in the Biolog microtiter plate that had affected the bacterial growth or survival. C/2 is half of the concentration of dipeptide used in the Biolog microtiter plate. 0 is Biolog medium with no dipeptide added. This medium was used in all the wells for the dipeptide experiments. The dipeptides used in this experiment were selected based on the effects observed in experiments using Biolog plates.