Antibiofilm Activity, Compound Characterization, and Acute Toxicity of Extract from a Novel Bacterial Species of Paenibacillus

Table 4

Liver and renal function tests among female rats.

	Female experiment groups			Contro (reference range)	International unit (IU)
	Vehicle (0.9% NaCl)	Low dose (2 gm/Kg)	High dose (4 gm/Kg)
Liver function test
Total protein	61.00±3.81^∗	71.66±0.95	63.16±2.46^∗	64–82	g/L
Albumin	15.83±3.00^∗	13.66±1.02^∗	16.66±5.74^∗	35–50	g/L
Globulin	45.83±3.77^∗	57.50±1.64^∗	48.16±4.85^∗	23–35	g/L
Total bilirubin	6.83±2.15	2.83±0.83^∗	4.66±1.76	3–17	µmol/L
Conjugate bilirubin	1.83±0.40	1.33±0.33	1.50±0.34	0–3	µmol/L
Alkaline phosphatase	156.33±38.10^∗	136.50±21.53^∗	140.00±23.42^∗	50–136	IU/L
Alanine aminotransferase	67.50±11.44^∗	67.50±3.19^∗	82.33±16.32^∗	30–65	IU/L
Aspartate aminotransferase	150.33±19.10^∗	196.66±19.69^∗	196.83±24.25^∗	15–37	IU/L
G-Glutamyltransferase	5.66±0.71^∗	4.50±0.56^∗	7.66±1.68^∗	15–85	IU/L
Renal function test
Sodium	139.50±0.99	138.00±1.06	138.50±0.84	136–145	mmol/L
Potassium	6.80±0.59^∗	6.10±0.65^∗	5.56±0.25^∗	3.6–5.2	mmol/L
Chloride	96.66±4.70^∗	100.66±1.05	98.50±2.61^∗	100–108	mmol/L
Carbon dioxide	24.68±1.04	27.03±1.35	26.66±1.37	21.0–30.0	mmol/L
Anion gap	24.68±1.04^∗	27.03±1.35^∗	26.66±1.37^∗	10–20	mmol/L
Urea	7.50±1.12^∗	7.15±0.32^∗	7.23±0.64^∗	2.5–6.4	mmol/L
Creatinine	23.33±2.76^∗	24.50±3.78^∗	28.66±1.20^∗	61.9–115	µmol/L

Values are expressed as the standard error mean ± S.E.M. and the significant value was at 𝑃<0.05.
*Values that are above or below the control reference range.
g/L: gram per liter, μmol/L: micromole per liter, and IU/L: international unit per liter.