Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy

Figure 1

TEM of S. typhimurium at 1 hr (a–e), 4 hrs (f–i), and 8 hrs (j and k) displaying various degrees of mitochondria destruction as a result of Salmonella infestation. In (a), mitochondria are shown (arrows) in which most of the cristae are destroyed. (c) through (e) show mitochondria with degraded cristae. (k) shows mitochondria within the PC-3M cell in which mitochondria (arrows) appear to be empty while the nucleus (labeled “N”) does not appear to be affected [10].