Figure 2: Hypothetical relationship between intrinsic therapeutic benefit and safety using Salmonella for bacteria mediated tumor therapy. Empirical observations support an inverse relationship between intrinsic therapeutic benefit and safety of treatment associated with Salmonella-based tumor therapy. Strain variants A–C in order of increased attenuation. Depicted are three scenarios, each intrinsically inadequate for achieving therapeutic success. Reinstalling/complementing an intrinsic therapeutic effect may be accomplished via recombinant strengthening without affecting the aforementioned intrinsic relationship.