Table 1: Recent representative preclinical examples of bacteria mediated tumor therapy (BMTT) in vivo from 2012 onwards.

SpeciesYearModelResultReferences

C. novyi2014Spontaneous, dogColonization and prolonged survival[34]
C. novyi2015Glioblastoma, ratColonization and prolonged survival[35]
B. infantis2013Bladder, ratHigh tumor specificity by engineered strain[129]
L. monocytogenes2014Ovary, mouseReprogramming of M2-M, iNOS-mediated tumor cell lysis[130]
L. monocytogenes
(ANZ-100)
2014Pancreas, mouseProlonged survival[131]
S. Typhimurium  
(A1-R)
2012Breast, nude mouseIntravenous administration most effective for tumor targeting[132]
S. Typhimurium  
(A1-R)
2012Brain, nude mouseTumor growth inhibition and prolonged survival[133]
S. Typhimurium  
(A1-R)
2014Bone metastasis, nude mouseInhibition of breast cancer bone metastasis[47]
S. Typhimurium  
(A1-R)
2014Pancreas, nude mouseTumor growth retardation, Α-VEGF supports therapy[134]
S. Typhimurium  
(A1-R)
2015Ovary, nude mouseProlonged survival, less metastasis formation[51]
S. Typhimurium2015Carcinoma (CT26), mouseComplete tumor rejection in all cases by recombinant strain[54]
E. coli2015Breast (4T1), mouseSecretion of toxic compound, reduced tumor volume[113]
La. acidophilus2014Carcinoma (CT26), mouseIncreased apoptosis and tumor growth suppression[135]

C. = Clostridium; B. = Bifidobacterium; L. = Listeria; S. = Salmonella; La. = Lactobacillus; E. = Escherichia.