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International Journal of Microbiology
Volume 2017, Article ID 8532736, 8 pages
Review Article

Automated Flow Cytometry: An Alternative to Urine Culture in a Routine Clinical Microbiology Laboratory?

1Department of Microbiology, Hospital del Oriente de Asturias Francisco Grande Covián, Arriondas, Asturias, Spain
2Department of Biochemistry, Hospital del Oriente de Asturias Francisco Grande Covián, Arriondas, Asturias, Spain

Correspondence should be addressed to Patricia Mejuto; moc.liamg@vlotujemaicirtap

Received 11 July 2017; Accepted 22 August 2017; Published 27 September 2017

Academic Editor: Maurizio Sanguinetti

Copyright © 2017 Patricia Mejuto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The urine culture is the “gold standard” for the diagnosis of urinary tract infections (UTI) but constitutes a significant workload in the routine clinical laboratory. Due to the high percentage of negative results, there is a need for an efficient screening method, with a high negative predictive value (NPV) that could reduce the number of unnecessary culture tests. With the purpose of improving the efficiency of laboratory work, several methods for screening out the culture-negative samples have been developed, but none of them has shown adequate sensitivity (SE) and high NPV. Many authors show data about the efficacy of flow cytometry in the routine clinical laboratory. The aim of this article is to review and discuss the current literature on the feasibility of urine flow cytometry (UFC) and its utility as an alternative analytical technique in urinalysis.