Current Progress in the Structural and Biochemical Characterization of Proteins Involved in the Assembly of Lipopolysaccharide

Figure 7

Structural dynamics of LpxH cap. PaLpxH ribbons are colored by fractional deuterium uptake at 10 min observed in hydrogen-deuterium exchange experiments of solubilized E. coli LpxH [52]. Blue indicates less deuterium uptake. (a) Closed/collapsed cap model observed in molecular dynamics simulations of PaLpxH-F82 G/L83 G [52]. (b) Lipid X-bound PaLpxH crystal structure (PDB: 5B49) [50]. (c). Open cap model observed in molecular dynamics simulations of PaLpxH without lipid X bound [52].

(a)

(b)

(c)