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Deep-sea Streptomyces-derived novel drugs |
Compound | Structural class | Source | Activity | Depth | Region | Reference |
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Caboxamycin | Benzoxazole | Streptomyces sp. NTK 937 | Antibacterial, antifungal, antitumor | 3814 m | Atlantic | [71] |
Ammosamides | Pyrroloiminoquinone | Streptomyces sp. CNR-698 | Cytotoxic | 1618 m | Bahamas | [72] |
Spiroindimicins | Bisindole alkaloid | Streptomyces sp. SCSIO 03032 | Cytotoxic | 3412 m | Indian Ocean | [73] |
Indimicins | Bisindole alkaloid | Streptomyces sp. SCSIO 03032 | Cytotoxic | 3412 m | Indian Ocean | [74] |
Grincamycins | Glycoside | Streptomyces lusitanus SCSIO LR32 | Cytotoxic | 3370 m | South China Sea | [75] |
Lobophorins E and F | Spirotetronate | Streptomyces sp. SCSIO 01127 | Cytotoxic, antibacterial | 1350 m | South China Sea | [76] |
Lobophorins H and I | Spirotetronate | Streptomyces sp. 12A35 | Antibacterial | 2134 m | South China Sea | [46] |
Marfuraquinocins | Sesquiterpenoid naphthoquinones | Streptomyces niveus SCSIO 3406 | Cytotoxic, antibacterial | 3536 m | South China Sea | [77] |
Sungsanpin | Peptide | Streptomyces sp. SNJ013 | Inhibitory activity to A549 with the cell invasion assay | 138 m | Jeju Island | [78] |
Ahpatinin | Peptide | Streptomyces sp. ACT232 | Aspartic protease inhibitors | 1174 m | Sagami Bay | [79] |
Desotamides B−D | Peptides | Streptomyces scopuliridis SCSIO ZJ46 | Antibacterial | 3536 m | South China Sea | [80] |
Marangucyclines A and B | Angucycline | Streptomyces sp. SCSIO 11594 | Cytotoxic, antibacterial | 2403 m | South China Sea | [47] |
Grincamycin H | Glycoside | Streptomyces lusitanus SCSIO LR32 | Cytotoxic | 3370 m | South China Sea | [81] |
Fradiamines A and B | Siderophore | Streptomyces fradiae MM456M-mF7 | Antibacterial | 806 m | Sagami Bay | [82] |
Lobophorin K | Lobophorin | Streptomyces sp. M-207 | Cytotoxic | 1800 m | Central Cantabrian Sea. | [83] |
Spiroindimicins G and H | Bisindole alkaloid | Streptomyces sp. SCSIO 03032 | Anticancer | 3412 m | South China Sea | [84] |
Atratumycin | Cyclodepsipeptide | Streptomyces atratus SCSIO ZH16 | Antituberculosis | 3536 m | South China Sea | [41] |
3-Hydroxyquinaldic acid derivative | | Streptomyces cyaneofuscatus M-157 | Cytotoxic | 2000 m | Central Cantabrian Sea | [85] |
Anthracimycin B | Macrolide | Streptomyces cyaneofuscatus M-169 | Antibacterial | 1500 m | Cantabrian Sea | [48] |
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Desert Streptomyces-derived novel antibacterial and cytotoxic drugs |
Compound | Structural class | Source | Activity | Region | Reference | |
|
Chaxalactins | Macrolactone polyketides | Streptomyces sp. strain C34 | Antibacterial | Atacama | [16] | |
Chaxamycins | Ansamycin-type polyketides | Streptomyces sp. strain C34 | Antibacterial | Atacama | [23] | |
Atacamycins | Macrolactone | Streptomyces sp. C38 | Enzyme inhibitor, antiproliferative | Atacama | [86] | |
Abenquines | Aminoquinone | Streptomyces sp. strain DB634 | Enzyme inhibitor for phosphodiesterase type 4b | Atacama | [59] | |
2-Amino-N-(2-amino-3-phenylpropanoyl)-N-hydroxy-3-phenylpropanamide | Hydroxamic acid | Streptomyces strain WAB9 | Antimicrobial | Saharan | [87] | |
Chaxapeptin | Peptide | Streptomyces leeuwenhoekii strain C58 | Inhibitory activity in a cell invasion assay with A549 | Atacama | [88] | |
Asenjonamides | Polyketide | Streptomyces asenjonii KNN 42.f | Antibacterial | Atacama | [21] | |
Pyridine-2,5-diacetamide | Pyridine alkaloid | Streptomyces sp. DA3-7 | Antibacterial | Saudi Arabian Desert | [63] | |
Grincamycins | Angucycline | Streptomyces sp. XZHG99 T | Cytotoxic | Color Desert | [89] | |
|
Low cold Streptomyces-derived antibacterial and cytotoxic drugs |
Compound | Structural class | Source | Activity | Region | Reference | |
|
2-Amino-3-dodecanol, norophthalmic acid, phthalic acid ester | | Streptomyces avidinii SB9 | Antibacterial | Arctic | [30] | |
Arcticoside, C-1027 chromophore-V | Benzoxazine | Streptomyces sp. ART5 | Cytotoxicity activity | Arctic | [69] | |
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Volcanic Streptomyces-derived antibacterial and cytotoxic drugs | |
Compound | Structure | Source | Activity | Region | Reference | |
|
Ohmyungsamycins A and B | Peptide | Streptomyces sp. SNJ042 | Antibacterial, cytotoxic | Korean volcanic | [35] | |
Ulleungdin | Lasso peptide | Streptomyces sp. KCB13F003 | Inhibited the invasion and migration of human lung carcinoma A549 | Korean volcanic | [37] | |
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