Mutant Prevention Concentration of Ciprofloxacin against Klebsiella pneumoniae Clinical Isolates: An Ideal Prognosticator in Treating Multidrug-Resistant Strains

Table 2

MPC, MIC, ESBL, AmpC, and carbapenemase detection in clinical isolates of K. pneumoniae.

S no.	Isolate no.	Source	MIC′	MPC′	Genes	ESBL	AmpC	Carbapenemases
1	28 (S)	Urine	≤0.25	25	—	+	−	−
2	56 (S)	Urine	≤0.25	50	—	−	−	−
3	126 (S)	Urine	1	25	—	+	+	+
4	198 (S)	Urine	≤0.25	3.125	—	−	−	−
5	210	Urine	≥4	175	—	−	−	+
6	211	Urine	≥4	100	—	+	−	+
7	212	Urine	≥4	12.5	—	−	+	+
8	213	Urine	≥4	125	qnrB	−	−	−
9	215	Urine	≥4	125	qnrB	−	+	+
10	217	Urine	≥4	175	qnrB	+	+	+
11	218	Urine	≥4	125	qnrS	−	+	+
12	219	Sputum	≥4	125	qnrB qnrS	−	+	+
13	220	Sputum	≥4	200	qnrB	+	+	+
14	221	Urine	≥4	100	—	−	−	−
15	222	Sputum	≥4	125	qnrB	+	−	−
16	223	Urine	≥4	125	—	−	+	−
17	224	Vaginal swab	≥4	100	—	+	−	−
18	230	Urine	≥4	100	qnrS	+	+	−
19	231	Urine	≥4	125	—	+	+	−
20	232	Vaginal swab	≥4	125	qnrB	+	+	−
21	233	Urine	≥4	125	qnrB	−	+	−
22	236	Urine	≥4	125	qnrS	+	−	−
23	239	Urine	≥4	100	—	+	+	−
24	240	Urine	≥4	100	—	+	+	−

S, susceptible to ciprofloxacin; , multidrug resistant; MIC′, minimum inhibitory concentration for ciprofloxacin in μg; MPC′, mutant prevention concentration for ciprofloxacin in μg.