The Inhibitory Effect of Validamycin A on Aspergillus flavus

Figure 1

Aspergillus flavus possesses trehalase homologs. (a) Percentages of identity and similarity of ScAth1p (YPR026W) : AFLA_090490 (B8NLC2) and Afu3g02280 (Q4WFG4) : AFLA_090490 (B8NLC2) from BLASTp analyses are 29% identity, 46% similarity and 68% identity, 81% similarity, respectively. ScAth1p, Saccharomyces cerevisiae acid trehalase protein; Afu, Aspergillus fumigatus; AFLA, Aspergillus flavus; glycosyl hydrolase family 65 (Glyco_hydro_65N; Glyco_hydro_65m) (adapted from SMART analyses (http://smart.embl-heidelberg.de/)).(b) Percentages of identity and similarity of ScNth1p (YDR001C) : AFLA_052438 (B8NS12) and Afu4g13530 (Q4WQP4) : AFLA_052438 (B8NS12) from BLASTp analyses are 55% identity, 69% similarity and 81% identity, 88% similarity, respectively. ScNth1p, Saccharomyces cerevisiae neutral trehalase protein; Afu, Aspergillus fumigatus; AFLA, Aspergillus flavus; Trehalase_Ca-bi: neutral trehalase calcium-binding domain; trehalase: trehalose hydrolysis domain (adapted from SMART analyses (http://smart.embl-heidelberg.de/)).

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