Research Article
Genomic and Pathogenic Characteristics of Virulent Newcastle Disease Virus Isolated from Chicken in Live Bird Markets and Backyard Flocks in Kenya
Table 4
Comparison of the amino acid residues at the antigenic sites of the hemagglutination neuraminidase protein of the Newcastle disease virus.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HN antigenic sites 1, 2, 3, 4, 12, 14, and 23 shown on the table are essential for receptor recognition. In the table are amino acid residue substitutions at different amino acid positions at the antigenic sites on the sequence of different Newcastle disease virus strains/genotypes compared to that of strain I-2 (AY935499). The amino acid residues shown are at position 345 of antigenic site 1; amino acid at positions 513, 514, 521, and 569 at antigenic site 2; amino acid at positions 263 and 287 at antigenic site 3; amino acid at positions 321, 333, and 356 at antigenic site 4; amino acid at positions 494 and 516 at antigenic site 12; amino acid at positions 347, 350, and 353 at antigenic site 14; amino acid at positions 193, 194, and 201 at antigenic site 23. The universal one-letter codes of the amino acid residues shown are interpreted as follows: P: proline; R: arginine; I: isoleucine; S: serine; D: aspartic acid; N: asparagine; K: lysine; E: glutamic acid; Y: tyrosine; L: leucine; H: histidine; V: valine; W: tryptophan; G: glycine; A: alanine; Q: glutamine. A blank at the residues shows that the sequence of the virus strain has an amino acid similar to that of I-2 Newcastle disease virus strain at that site. |