Research Article
Antifungal Activity of Thai Cajuput Oil and Its Effect on Efflux-Pump Gene Expression in Fluconazole-Resistant Candida albicans Clinical Isolates
Table 2
Efflux-pump gene patterns among resistant strains and antifungal activity of Thai Cajuput oil.
| | Efflux-pump gene patterns | Resistant strains | MICFLCa (μg/ml) | MICCajuput oila (μl/ml) | MFCCajuput oila(μl/ml) | MFC/MIC ratio | Antifungal activity |
| | A: CDR1, CDR2, and MDR1 | S7/1 | 8 | 1.25 | 1.25 | 1 | Fungicidal | | S8/1 | 16 | 1.25 | 1.25 | 1 | Fungicidal | | S9/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal | | S10/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal | | S14/1 | 8 | 1.25 | 1.25 | 1 | Fungicidal | | S15/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal | | U6/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal | | U6/2 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal | | U7/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal | | U25/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal |
| | B: CDR1 and MDR1 | U15/1 | ≥64 | 1.25 | 1.25 | 1 | Fungicidal |
| | C: MDR1 | U8/1 | 16 | 1.25 | 1.25 | 1 | Fungicidal | | U11/1 | 16 | 0.31 | 0.63 | 2 | Fungicidal | | U21/1 | 16 | 0.63 | 1.25 | 2 | Fungicidal |
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aData are presented as the mean of three independent experiments and presented relative to control.
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