Research Article
Antifungal Activity of Thai Cajuput Oil and Its Effect on Efflux-Pump Gene Expression in Fluconazole-Resistant Candida albicans Clinical Isolates
Table 3
Efflux-pump gene patterns among resistant strains and antifungal activity of Thai Cajuput oil.
| | Efflux-pump gene patterns | Resistant strains | Drugs | MIC alonea | MIC combinationa | FIC | FICI | Interpretation |
| | A: CDR1, CDR2, and MDR1 | S7/1 | FLC | 8 | 1 | 0.125 | 0.189 | Synergistic | | Cajuput oil | 1.25 | 0.08 | 0.064 | | U6/2 | FLC | 64 | 2 | 0.031 | 0.159 | Synergistic | | Cajuput oil | 1.25 | 0.16 | 0.128 |
| | B: CDR1 and MDR1 | U15/1 | FLC | 64 | 1 | 0.016 | 0.144 | Synergistic | | Cajuput oil | 1.25 | 0.16 | 0.128 |
| | C: MDR1 | U8/1 | FLC | 16 | 16 | 1 | 1.032 | Indifferent | | Cajuput oil | 1.25 | 0.04 | 0.032 |
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aData are presented as the mean of three independent experiments and presented relative to control.
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