An Overview of the Molecular Methods in the Diagnosis of Gastrointestinal Infectious Diseases

Table 2

Comparative summary of commercial enteropathogen multiplex PCR assays.

Product name	BioFire® FilmArray® Gastrointestinal (GI) Panel FDA/CE-IVD	xTAG® Gastrointestinal Pathogen Panel FDA/CE-IVD	Verigene® Enteric Pathogens TestFDA/CE-IVD	Prodesse® ProGastro™ SSCS assay FDA/CE-IVD	BD MAX™ Enteric Bacterial, Ext Bacterial, Parasite, and Viral Panels FDA/CE-IVD	Stool Bacterial Pathogens Panel FDA/CE-IVD
Manufacturer	BioFire, Salt Lake City, UT, USA	Luminex, Austin, TX, USA	Luminex, Austin, TX, USA	Hologic, San Diego, CA, USA	BD, Sparks, MD, USA	Great Basin Scientific, Salt Lake City, UT, USA
Bacteria
Campylobacter spp	√C. jejuni, C. coli, C. upsaliensis	√	√C. jejuni, C. coli, and C. lari	√C. jejuni, C. coli	√	√C. jejuni, C. coli
Clostridioides difficile	√Toxin A/B	√Toxin A/B
Plesiomonas shigelloides	√
Salmonella spp	√	√	√	√	√	√
Yersinia enterocolitica	√	√	√		√
Vibrio spp	√V. cholera, V. parahaemolyticus, V. vulnificus	√V. cholera	√V. cholera, V. parahaemolyticus		√V. cholera, V. parahaemolyticus, V. vulnificus
Enteroaggregative E. coli (EAEC)	√
Enteropathogenic E. coli (EPEC)	√
Enterotoxigenic E. coli (ETEC) lt/st	√	√			√
Shiga-like toxin-producing E. coli (STEC) stx1/stx2	√		√	√	√	√
E. coli O157	√	√				√
Enteroinvasive E. coli (EIEC)/Shigella spp	√	√	√S. dysenteriae, S. boydii, S. sonnei, and S. flexneri	√	√	√Shigella spp
Viruses
Adenovirus	√F40/41	√F40/41			√F40/41
Astrovirus	√				√
Norovirus	√GI/GII	√GI/GII	√GI/GII		√
Rotavirus	√A	√A	√A		√A
Sapovirus	√I, II, IV, and V				√
Parasites					√F40/41
Cryptosporidium spp	√	√			√C. parvum, C. hominis
Cyclospora cayetanensis	√
Entamoeba histolytica	√	√			√
Giardia lamblia	√	√			√

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