Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of Astragalus candolleanus against Clinically Significant Bacterial Strains
Table 8
Swiss Target Prediction for the bioactive isolate.
S. no.
Name of the compound
Target
Common name
UNIPROT ID
CHEMBL ID
Target class
Probability
Known active (3D/2D)
1
Scillirosidin
MAP Kinase p38 alpha
MAPK14
Q16539
CHEMBL260
Kinase
0.100634432184
158/0
MAP Kinase P38 beta
MAPK11
Q15759
CHEMBL 3961
Kinase
0.100634432184
176/0
Interleukin-8 receptor B
CXCR2
P25025
CHEMBL 2434
Family AG-protein coupled receptor
0.100634432184
108/0
2
Cephalotaxine
Inhibitor of apoptosis protein 3
X1AP
P98170
CHEMBL 4198
Other cytosolic proteins
0.0
16/0
3
Stemmadenine
Inhibitor of apoptosis protein 3
X1AP
P98170
CHEMBL 4198
Other cytosolic proteins
0.109339753231
116/0
4
Myxoxanthophyll
Interleukin-2 (IL-2)
IL-2
P60568
CHEMBL5880
Secreted protein
0.428381527054
0/1
Interleukin-8 receptor
CXCR1
P25024
CHEMBL4029
Family AG-protein coupled receptor
0.0
0/2
Probability for the query molecule assumed as bioactive to have this protein as target.
