Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of Astragalus candolleanus against Clinically Significant Bacterial Strains

Table 9

PASS online predictivity score for bioactive compounds.

S. no	Name of isolated phytoconstituent	PASS (activity)/(inactivity) prediction score Pa pi		Key mechanism of bioactivity
1	Scillirosidin (moderately active)	0.43200.33900.; 25300.33700.1600	0.0590.0460.; 0160.1310.017	Apoptosis agonist; Antibacterial; Transcription factor kappa B inhibitor; Anti-inflammatory; Cytokine release inhibitor
2	Cephalotaxine (high activity)	0.92300.19100.0660	0.0600.0040.058	Antioxidants; Apoptosis agonist; Glutathione reductase stimulant
3	Stemmadenine (moderately active)	0.37900.34200.35500.0970	0.830.621.190.87	Apoptosis agonistMAP3K5 inhibitorAnti-inflammatoryMAP kinase inhibitor
4	Myxoxanthophyll (high activity)	0.86600.82700.71700.21900.1230	0.050.0030.0140.0160.031	Apoptosis agonist; Antioxidant; Anti-inflammatory; Interferon antagonist; Cytokine release inhibitor

Pa > 0.7: highly active; Pa > 0.3: moderately active; Pa > 0.1: less active.