Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo

Figure 7

Histopathological sections analysis to the treated and untreated AN3 mouse mammary adenocarcinoma tumor (H&E). (a) Control hyperchromatic tumor cells with a high nuclear-cytoplasmic ratio (×40). (b) Tumor section in the NDV-treated group after 30 days of treatment showing tumor necrosis with tissue debris, replacement of tumor cell with fibrous connective tissue, hemorrhage, and infiltration of mononuclear cells, lymphocytes (×40). (c) Tumor section in the papaverine-treated group after 30 days of treatment shows necrotic and apoptotic tumor cells aggregation, hemorrhage and lymphocyte infiltration. Tumor section treated after the combination-treated group after 30 days of treatment with extensive necrotic area with nuclear debris and residue of the cytoplasm and a mixture of apoptotic and necrotic cells with infiltration of inflammatory cells and fibrosis. (d) Combination.

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