Research Article

Analysis of Fractional Order Mathematical Model of Hematopoietic Stem Cell Gene-Based Therapy

Table 4

Parameters value of the model.

ParameterDescriptionValueSource

Production rate of uninfected CD4+ T cells0.2[14]
Death rate of uninfected CD4+ T cells0.05Assumption
Infection rate0.15[14].
Death rate of infected CD4+ T cells0.8[14]
Effector CTL rate of killing infected CD4+ T cells0.016[14]
Fractions of HSCs that successfully differentiated into functional CTL cells0.01Assumption
Proliferation rate of precursor CTL0.1Assumption
Fraction of precursor CTL cells that differentiated into effector CTL cells0.1Assumption
Death rate of precursor CTL0.05[14]
Death rate of effector CTL0.05[14]
Differentiation rate of CD8+ T cells0.005Assumption