Table of Contents Author Guidelines Submit a Manuscript
International Journal of Nephrology
Volume 2010 (2010), Article ID 383548, 3 pages
Case Report

Severe Relapsing Goodpasture's Disease Successfully Treated with Mycophenolate Mofetil

Serviço de Nefrologia, Hospital de Faro, Rua Leão Penedo, 8000 Faro, Portugal

Received 21 April 2010; Revised 22 June 2010; Accepted 14 July 2010

Academic Editor: Tibor Nadasdy

Copyright © 2010 Anabela Malho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Goodpasture's disease is a rare autoimmune disorder characterised by the development of antiglomerular basement membrane autoantibodies, which typically presents with rapidly progressive crescentic glomerulonephritis and pulmonary haemorrhage. Even with aggressive nonspecific immunosuppression and plasma exchange, mortality remains high. We report a case of life-threatening Goodpasture's disease with relapsing pulmonary haemorrhage refractory to conventional therapy. Second line treatment was based on mycophenolate mofetil 1 g every 12 hours and prednisolone 60 mg/day. In this case, the use of a low-dose mycophenolate mofetil regimen turned out to be insufficient. However, in our opinion higher mycophenolate mofetil doses should be considered an alternative treatment, mainly in relapsing disease, due to its mechanism of action and current insufficient therapeutic weapons.