Summary of biopsy proven cases of oxalate nephropathy secondary to ascorbic acid reported in the literature.
Patient (Ref. Num.)*
Age
Gender
Baseline Serum creatinine (mg/dl)
Renal presentation and serum creatinine (Cr) in mg/dl
Dose of ascorbic acid per day
Duration of administration
Treatment
Outcome
20
71
Female
1.4
Anuria (Cr = 12.1)
500 mg (oral)
6 months
HD
ESRD
15**
58
Female
1.0
Oliguria (Cr = 3.5 )
45 g (IV)
1 day
HD
Death
21***
72
Male
Unknown
Anuria(Cr = 15.3)
Grams (oral)
Months
Medical
Death
22
73
Male
1.2
Poor renal clearance (Cr = 8.4)
680 mg (oral)
4 months
HD
Recovery Cr = 1.8 mg/dl
23
31
Male
Unknown
Poor renal clearance (Cr = 10.1)
2.5–5.0g (oral)
Undisclosed (week to months?)
HD
Recovery Cr = 2.2 mg/dl
24
49
Female
0.7
Oliguria (Cr = 4.5)
4.0 g (oral)
Several months
HD
Recovery Cr = 1.1 gm/dl
10
58
Male
1.4
Anuria (undisclosed)
1 g (IV)
2 months
HD
Recovery Cr = 1.4 mg/dl
14
61
Male
1.3
Anuria (Cr = 13.3)
60 g (IV)
1 day
Medical
Recovery Cr = 2.9 mg/dl
The ref. num. identifies the individual case report. Please refer to the listed references at the end of the article to locate any particular case report by its reference number. The patient died from multiple organ failure. Her systemic illness was amyloidosis. The patient died from renal failure and associated multiple organ failure as he did not want to undergo dialysis.
