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International Journal of Nephrology
Volume 2011, Article ID 256420, 5 pages
Clinical Study

Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome

1Radiation Medicine Centre, Bio-Medical Group, Bhabha Atomic Research Centre (BARC), Tata Memorial Hospital Annexe Building, Parel, Mumbai 400 012, India
2Artificial Kidney Division, Department of Nephrology, King Edward VII Memorial Hospital, Parel, Mumbai 400 012, India

Received 12 April 2011; Revised 15 June 2011; Accepted 7 July 2011

Academic Editor: R. Khanna

Copyright © 2011 Sangita U. Sawant et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The present study is to look for a correlation between oxidative stress and thyroid function in patients with the nephrotic syndrome in the remission phase as well as in a persistent proteinuric state. Introduction. Nephrotic syndrome is a form of chronic kidney disease due to which blood loses protein through the urine. We wanted to know if there was an increased loss of thyroid hormones in urine affecting thyroid function. Methods. 60 patients with nephrotic syndrome and 20 healthy non-proteinuric individuals as control subjects were enrolled in the study. We measured their serum tri-iodothyronine, thyroxine and thyroid-stimulating hormone. Estimation of lipid peroxidation (LPx) catalase, superoxide dismutase (SOD), and Glutathione peroxidase (GPx) were carried out by standard methods. Results. TSH was elevated in the nephrotic patients compared to controls, while TT4 and TT3 were significantly lower in the patients than in controls. Lipid Peroxidation and GPx were significantly higher in the nephrotic syndrome patients than in the controls, while SOD and catalase were significantly lower than in patients than in the control subjects. Conclusion. Nephrotic patients can lose significant amounts of thyroid hormones along with protein in urine, which can affect thyroid status, but this is reversible on remission.