Figure 3: The role of fructose and Glut5 in fructose absorption and fructose-stimulated salt absorption in the small intestine. Luminal fructose is predominantly absorbed via Glut5 action and stimulates PAT1 and NHE3, therefore enhancing salt absorption in the jejunum. The stimulatory effect of luminal fructose on salt absorption in jejunum was completely abrogated in Glut5 null mice (see [12]).