Recurrent Focal Segmental Glomerulosclerosis in Renal Allograft Recipients: Role of Human Leukocyte Antigen Mismatching and Other Clinical Variables
Table 4
(a) Acute Rejection in renal allograft recipients from 1990 to 2007 at Montefiore Medical Center. (b) Subgroup of subjects with acute rejection adjusted for FSGS recurrence in renal allograft recipients from 1990 to 2007 at Montefiore Medical Center.
(a)
Data of adult and pediatric patients combined
All transplants for primary FSGS ()
Acute Rejection ()
No-rejection ()
value
Number of HLA matches
0
37 (28%)
10 (26%)
27 (29%)
.36
1
23 (18%)
12 (31%)
11 (12%)
2
27 (21%)
6 (15%)
21 (23%)
3
21 (16%)
5 (13%)
16 (17%)
4
13 (10%)
4 (10%)
9 (10%)
5
4 (3%)
1 (3%)
3 (3%)
6
4 (3%)
1 (3%)
3 (3%)
HLA < 3
42 (32%)
18 (46%)
24 (26%)
.73
HLA ≥ 3
10 (8%)
5 (13%)
5 (5%)
PRAm
26.83 ± 3.04
32.75 ± 5.28
23.76 ± 3.67
.054
PRAc
30.19 ± 3.65
36.35 ± 6.08
26.73 ± 4.52
.068
PRA < 30
32 (24%)
10 (26%)
22 (24%)
.080
PRA ≥ 30
11 (84%)
7 (38%)
4 (4%)
Hypertension
63 (48%)
15 (38%)
48 (52%)
.25
HTNc
38 (29%)
8 (21%)
30 (33%)
.032
Data for subgroup of pediatric patients
All transplants for primary FSGS ()
Acute Rejection ()
No-rejection ()
value
Number of HLA matches
0
16 (33%)
6 (29%)
10 (36%)
.59
1
10 (20%)
6 (29%)
4 (14%)
2
14 (29%)
5 (24%)
9 (32%)
3
4 (8%)
1 (5%)
3 (11%)
4
5 (10%)
3 (14%)
2 (7%)
5
0 (0%)
0 (0%)
0 (0%)
6
0 (0%)
0 (0%)
0 (0%)
HLA < 3
40 (81%)
17 (81%)
23 (82%)
.99
HLA ≥ 3
9 (18%)
4 (19%)
5 (18%)
PRAm
16.68 ± 3.52
26.75 ± 6.86
10.24 ± 3.27
.024
PRAc
18.68 ± 5.17
31.55 ± 9.41
8.57 ± 4.08
.026
PRA < 30
30 (61%)
9 (29%)
21 (75%)
.14
PRA ≥ 30
10 (20%)
6 (29%)
5 (18%)
Hypertension
28 (57%)
11 (52%)
17 (61%)
.77
HTNc
15 (31%)
5 (24%)
10 (36%)
.13
PRAc: PRA peak, mean corrected to exclude FSGS recurrence cases. HTNc: for cadaveric donors.
(b)
Adult and pediatric patients with acute rejection and recurrence of FSGS
