International Journal of Nephrology / 2011 / Article / Tab 3

Review Article

Hepatitis C and Kidney Transplantation

Table 3

Predictive value of serological markers for advanced liver fibrosis in HCV+ patients with end-stage renal disease.

Components of the testCutoffsAuthorsSample SizeAUROCPPVNPV

APRIAST-to-Platelets-Ratio<0.4 = no advanced fibrosis
>0.9 = advanced fibrosis
Schiavon et al. [103]2030.866%93%
Liu et al. [104]2790.8385%82%
Schiavon et al. [105]1850.7866%93%

Fibrotestα2 macroglobulin, haptoglobin, γ-glutamyl transpeptidase, total bilirubin and apolipoprotein A1 levels<0.2 = no advanced fibrosis
>0.6 = advanced fibrosis
Varaut et al. [106]500.4771%77%
Canabakan et al. [107]330.4620%45%

Hyaluronic AcidUnbranched, high-molecular weight polysaccharide that is widely distributed in the extracellular spaces<64 = no advanced fibrosis
>205 = advanced fibrosis
Schiavon et al.[105]1850.6542%86%

YKL-40Glycoprotein with function in the remodelling of the extracellular matrix or in tissue inflammation<290 = no advanced fibrosis
>520 = advanced fibrosis
Schiavon et al. [105]1850.635%84%