Hepatitis C and Kidney Transplantation

Table 3

Predictive value of serological markers for advanced liver fibrosis in HCV+ patients with end-stage renal disease.

	Components of the test	Cutoffs	Authors	Sample Size	AUROC	PPV	NPV
APRI	AST-to-Platelets-Ratio	<0.4 = no advanced fibrosis; >0.9 = advanced fibrosis	Schiavon et al. [103]	203	0.8	66%	93%
			Liu et al. [104]	279	0.83	85%	82%
			Schiavon et al. [105]	185	0.78	66%	93%
Fibrotest	α2 macroglobulin, haptoglobin, γ-glutamyl transpeptidase, total bilirubin and apolipoprotein A1 levels	<0.2 = no advanced fibrosis; >0.6 = advanced fibrosis	Varaut et al. [106]	50	0.47	71%	77%
			Canabakan et al. [107]	33	0.46	20%	45%
Hyaluronic Acid	Unbranched, high-molecular weight polysaccharide that is widely distributed in the extracellular spaces	<64 = no advanced fibrosis; >205 = advanced fibrosis	Schiavon et al.[105]	185	0.65	42%	86%
YKL-40	Glycoprotein with function in the remodelling of the extracellular matrix or in tissue inflammation	<290 = no advanced fibrosis; >520 = advanced fibrosis	Schiavon et al. [105]	185	0.6	35%	84%