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International Journal of Nephrology
Volume 2011, Article ID 626178, 4 pages
http://dx.doi.org/10.4061/2011/626178
Research Article

Comparison of Measured Creatinine Clearance and Clearances Estimated by Cockcroft-Gault and MDRD Formulas in Patients with a Single Kidney

Medical School, Federal University of Uberlândia, Uberlândia MG, Brazil

Received 12 January 2011; Revised 7 April 2011; Accepted 12 April 2011

Academic Editor: Jaime Uribarri

Copyright © 2011 Sebastião Rodrigues Ferreira-Filho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There are doubts about whether the values obtained from the Cockroft-Gault (ClCG) and Modification of Diet in Renal Disease (GFRMDRD) formulas are comparable to the more traditional formula used to obtain the creatinine clearance from a 24-hour urine collection (ClCrm), particularly in patients with only one kidney. The present study aimed to compare these formulas in individuals with one remaining kidney after previous nephrectomy (Nx) and to verify which estimated formula correlates more closely with ClCrm. Thirty-six patients who had undergone Nx had their renal filtration analyzed with ClCG, GFRMDRD and by ClCrm. The average time after Nx was 1 1 . 6 ± 9 . 0 years, and the average age at the time of the study was 5 0 . 7 ± 1 0 . 6 years old (X ± SD). The results of three clearances were 8 1 . 1 ± 3 5 . 6  mL·min·m2 for ClCrm, 7 0 . 4 ± 2 4 . 0 mL·min·m2 for ClCrCG, and 7 1 . 2 ± 1 9 . 2 mL·min·m2 for GFRMDRD (with ClCrm > ClCrCG and GFRMDRD; 𝑃 < . 0 0 1 ). No difference was found between the ClCrCG and GFRMDRD values ( 𝑃 = . 7 2 ). The data demonstrated that both estimate formulas were strongly correlated with ClCrm, although ClCrCG was more closely associated with ClCrm than GFRMDRD (ClCrCG with 𝑟 2 0 . 6 4 and GFRMDRD with 𝑟 2 0 . 3 4 ; 𝑃 < . 0 0 1 ). In conclusion, for people with only one kidney remaining after NX, our data showed that glomerular filtration rate estimation by ClCrCG is more related to the values obtained with the traditional clearance measurement based on a 24-hour urine collection test.