Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications: A Review of Clinical Trials on CKD Patients

Table 1

A study analyzing the effect of non-calcium-based phosphate binders.

Reference	Study	Patient population	Comparison		Study design	Results
Block et al. [15]	RIND	Incident HD	Calcium (55)	Sevelamer (54)	Randomly assigned	Calcium binders resulted in more increase in CACS versus sevelamer at 18 months (𝑃=.015); median increase in CACS was 11 times greater with calcium versus sevelamer (𝑃=.01)
Chertow et al. [24]	TTG	Prevalent HD	Calcium (75)	Sevelamer (66)	Randomly assigned	Calcium binders with greater percentage of CACS versus sevelamer at 26 and 52 wk; 𝑃=.02, 𝑃=.04
Qunibi et al. [31]	CARE-2	Prevalent HD	Calcium (58)	Sevelamer (68)	Randomly assigned with atorvastatin to both binders or 52 wk	Nonsignificative differences in CACS between calcium and sevelamer
Barreto et al. [32]	BRiC	Prevalent HD	Calcium (18)	Sevelamer (11)	Randomly assigned	Nonsignificative differences in CACS between calcium and sevelamer
Boaz et al. [35]	N/A	Predialysis pts	Calcium (28)	Sevelamer (27)	Low-phosphorus diet with both binders	Increase in TCS with calcium to baseline (𝑃=.001); NS with sevelamer