Review Article
Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications: A Review of Clinical Trials on CKD Patients
Table 2
A study analyzing the effect of non-calcium-based phosphate binders.
| | Reference | Study | Patient population | Comparison | Study design | Results |
| | Chue et al. [51] | N/A | Prevalent HD | Calcium (13) | Lanthanum (17) | Randomly assigned | Lanthanum reduced progression of aortic VC () versus calcium |
| | Raggi et al. [25] | N/A | Prevalent HD | Calcium (130) | Sevelamer (132) | Observation at 52 wk | Sevelamer arrested the progression of valvular and vascular calcification () versus calcium |
| | Galassi et al. [28] | N/A | Incident HD | Calcium (20ND, 25D) | Sevelamer (13ND, 27D) | Randomly assigned | Hemodialysis diabetic at 18 months, a greater progression of CACS () than with sevelamer with iPTH ranges suggestive of low bone turnover |
| | Takei et al. [45] | N/A | Prevalent HD | Calcium (21) | Sevelamer (21) | Randomly assigned | Sevelamer suppresses progressive aortic calcification more than with calcium |
| | Raggi et al. [34] | SUMMER | Prevalent HD | Calcium (130) | Sevelamer (45) | Cross-sectional | Less carotid and femoral intima media thickness, minor levels of LDL-cholesterol, higher iPTH with sevelamer versus calcium |
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