Urea ≤ 24.5 Or Cr ≤ 309 Or <2 days from ICU admission
Urea ≥ 24.5 Or Cr ≥ 309 Or >5 days from ICU admission
63.4 (urea) 53.4 (Cr) 59 (time)
61.4 (urea) 71.4 (Cr) 72.8 (time)
<.001 (stratified by days since ICU admission)
SI units for urea (mmol/L) and Cr (μmol/L) and K(mmol/L).
*Patients randomly assigned when serum Cr reached 707 μmol/L to maintain predialysis urea/Cr to early and late criteria as listed.
**Patients assigned to 3 treatment groups: early high volume (HV) CVVHDF, early low volume (LV) CVVHDF, and late low volume (LV) CVVHDF.
***Early and late RRT assessed separately by urea, Cr and time in ICU criteria.