| | Total | WRF absent | WRF present | -value | | () | () | () | |
| | Demographics | | | | | | Age (mean, SD) | 77.9 (10.1) | 77.8 (10.3) | 79.2 (8.4) | .380 | | Age years | 274 (69.5) | 239 (68.1) | 35 (81.4) | .074 | | Males | 266 (67.5) | 236 (67.2) | 30 (69.8) | .738 | | Medical history | | | | | | Prior heart failure | 243 (61.7) | 218 (62.1) | 25 (58.1) | .613 | | Diabetes | 130 (33.0) | 108 (30.8) | 12 (27.9) | .700 | | Valvular disease | 108 (27.4) | 99 (28.2) | 9 (20.9) | .313 | | COPD | 122 (30.9) | 111 (31.6) | 11 (25.6) | .418 | | Hypertension | 230 (58.4) | 201 (57.3) | 29 (67.4) | .201 | | Peripheral vascular disease (PVD) | 74 (18.8) | 67 (19.1) | 7 (16.3) | .656 | | Previus acute coronary syndrome | 226 (57.4) | 204 (58.1) | 22 (51.2) | .384 | | Prior renal failure | 95 (24.1) | 76 (21.6) | 19 (44.2) | .001 | | Clinical and laboratory parameters | | | | | | Systolic blood pressure, mm Hg (mean, SD) | 132 (25.5) | 131 (25.1) | 137 (29.1) | .138 | | Systolic blood pressure >160 mm Hg | 43 (10.9) | 36 (10.3) | 7 (16.3) | .230 | | Serum creatinine, mg/dL (mean, SD) | 1.5 (0.8) | 1.47 (0.8) | 1.71 (0.9) | .066 | | Creatinine mg/dL | 111 (28.2) | 92 (26.2) | 19 (44.2) | .013 | | GFR, mL/min (mean, SD) | 54 (23.5) | 55 (22.8) | 51 (28.4) | .070 | | GFR mL/min | 239 (60.7) | 207 (59.0) | 32 (74.4) | .055 | | Sodium, mEq/L (mean, SD) | 140 (4.4) | 140 (4.5) | 140 (3.5) | .854 | | Potassium, mEq/L (mean, SD) | 4.0 (0.6) | 4.0 (0.6) | 3.9 (0.6) | .219 | | Glycemia, mg/dL (mean, SD) | 76 (73.0) | 78 (74.6) | 58 (56.6) | .114 | | Haemoglobin, gr/dL (mean, SD) | 12.6 (6.5) | 12.7 (1.8) | 12.1 (6.9) | .387 | | Anaemia (hemoglobin 12 gr/dL) | 167 (42.4) | 147 (41.9) | 20 (46.5) | .562 | | Haematocrit (mean, SD) | 38 (6.1) | 39 (6.2) | 38 (5.2) | .502 | | Azotemia, mg/dL (mean, SD) | 46 (50.0) | 45.5 (49.1) | 50.2 (60.5) | .561 | | NYHA class (mean, SD) | 3.3 (0.7) | 3.3 (0.6) | 3.3 (0.7) | .778 | | NYHA class III-IV | 353 (89.6) | 316 (90.0) | 37 (86.0) | .420 | | KILLIP (mean, SD) | 2.4 (0.6) | 2.3 (0.6) | 2.4 (0.6) | .363 | | Doppler echocardiography | | | | | | Ejection fraction (mean, SD) | 39.6 (12.2) | 39.5 (12.2) | 39.7 (12.4) | .942 | | Ejection fraction 45% | 241 (61.2) | 215 (61.3) | 26 (60.5) | .869 | | Left atrial size, mm (mean, SD) | 46.3 (7.3) | 46.4 (7.5) | 45.2 (6.0) | .343 | | Left ventricular size, mm (mean, SD) | 58.5 (9.5) | 58.4 (10.0) | 58.1 (6.7) | .982 | | Left atrial dilatation | 232 (58.9) | 211 (60.1) | 21 (48.8) | .279 | | Left ventricular dilatation | 265 (67.3) | 237 (67.5) | 28 (65.1) | .880 | | Elettrocardiogram | | | | | | LBBB | 45 (11.4) | 40 (11.4) | 5 (11.6) | .960 | | Heart rate, bpm (mean, SD) | 85.3 (17.0) | 85 (17.0) | 88 (16.3) | .276 | | Heart rate bpm | 80 (20.3) | 64 (18.2) | 16 (37.2) | .003 | | Atrial fibrillation | 164 (41.6) | 149 (42.4) | 15 (34.9) | .342 | | Medical treatments | | | | | | Aldosterone antagonists | 88 (22.3) | 76 (21.6) | 12 (27.9) | .352 | | Diuretics | 285 (72.3) | 255 (72.5) | 30 (69.8) | .690 | | Beta-blockers | 109 (27.7) | 98 (27.9) | 11 (25.6) | .746 | | Calcium channell blockers | 60 (15.3) | 49 (14.0) | 11 (25.6) | .045 | | ACE inhibitors | 215 (54.7) | 190 (54.1) | 25 (58.1) | .618 | | ARBs | 37 (9.4) | 30 (8.5) | 7 (16.3) | .101 | | Statins | 46 (11.7) | 40 (11.4) | 6 (14.0) | .865 | | ASA | 163 (41.4) | 143 (40.7) | 20 (46.5) | .468 | | Warfarin | 101 (25.6) | 91 (25.9) | 10 (23.3) | .705 | | Nitrates | 144 (36.5) | 133 (37.9) | 11 (25.6) | .114 | | Digoxin | 99 (25.1) | 95 (27.1) | 4 (9.3) | .006 |
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