International Journal of Nephrology / 2011 / Article / Tab 3

Review Article

The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat

Table 3

The effect of fructose feeding on kidney morphology, function, and haemodynamics in rat.

Amount fedLength of studyEffectReference

60% fructose in diet4 weeks Urine volume, sodium excretion, creatinin clearance[76]
4 weeks Urine volume, sodium excretion, RBF, CBF, MBF[81]
6 month Serum creatinine, BUN[47]
8 weeksKidney hypertrophy, glomerular hypertension, cortical vasoconstriction, arteriolopathy[11]
12 monthsGlomerular sclerosis, albuminurea, ↑ kidney weight[199]
60 days↑ Plasma and urine urea level, ↑ plasma and urine uric acid,
↑ plasma and urine creatinine, ↑ plasma and urine albumin and total protein, fatty infiltration, thickening of glomeruli
30 days↑ Plasma sodium, sodium excretion, ↑ urine volume[191]
8 weeks GFR; afferent arteriole resistance; efferent arteriole resistance glomerular hypertension, cortical vasoconstriction, arteriolopathy[67]
6 weeksKidney hypertrophy, tubular proliferation, and focal injury[201]
66% fructose in diet6 weeks Urine volume, sodium excretion[192]
8 weeks Kidney weight, RBF, urine volume, sodium excretion[156]
65% fructose in diet4 weeks↑ Kidney weight, swollen proximal tubular cells[202]
57% fructose in diet10 weeks Plasma creatinine, ↑ kidney weight[36]
10% fructose in drinking water8 weeksKidney hypertrophy, glomerular hypertension, cortical vasoconstriction, and arteriolopathy[11]
20% fructose in diet9 weeks↑ Kidney weight[203]
25% fructose in diet2 weeks↑ Creatinine clearance, hyperfiltration, mesangial cells proliferation[204]
20% fructose in drinking water8 weeks Kidney weight, CBF, RAP[16]

RBF: Renal Blood Flow, CBF: Cortical Blood Flow, MBF: Medullary Blood Flow, BUN: Blood Urea Nitrogen, GFR: Glomerular Filtration Rate, RAP: Renal Arterial Pressure. ↑, and indicate increase, decrease, and no effect, respectively.

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