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International Journal of Nephrology
Volume 2011 (2011), Article ID 982854, 9 pages
http://dx.doi.org/10.4061/2011/982854
Review Article

Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations

1Department of Nephrology, Royal Brisbane and Women’s Hospital, Queensland Health, Butterfield Street, Herston, QLD 4029, Australia
2Department of Anatomical Pathology, Royal Brisbane and Women’s Hospital, Queensland Health, Butterfield Street, Herston, QLD 4029, Australia
3School of Medicine, The University of Queensland, Brisbane, QLD 4027, Australia

Received 1 March 2011; Revised 11 April 2011; Accepted 14 April 2011

Academic Editor: Hulya Taskapan

Copyright © 2011 Nicholas New et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Calciphylaxis or calcific uremic arteriolopathy is an infrequent complication of end stage kidney disease. It is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, tissue necrosis often leading to ulceration, secondary infection and increased mortality rates. Current, multimodality treatment involves local wound care, well-controlled calcium, phosphate and parathyroid hormone levels and combination therapy with sodium thiosulfate and hyperbaric oxygen therapy. This combination therapy may be changing the historically poor prognosis of calcific uremic arteriolopathy reported in the literature. Peritoneal dialysis is considered a risk factor based on limited publications, however this remains to be proven. Clinical presentation, diagnosis, pathogenesis and treatment of calcific uremic arteriolopathy in these patients are no different from other patients manifesting with this condition.