Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model
Figure 2
Serum difference levels (one week after CP administration − before CP administration; Δ) of BUN, Cr, Mg, SOD, estradiol, and nitrite; the kidney and the uterus weights; and KTDS in estradiol and CP, estradiol plus vitamin E and CP, estradiol plus vitamin C and CP, estradiol plus losartan and CP-treated ovariectomized groups (group 1–4) compared with ovariectomized rats treated with CP alone (positive control group). CP, CPE, CPEVE, CPEVC, and CPEL on the horizontal axes stand for groups treated with CP alone (group 5), estradiol and CP (group 1), estradiol plus vitamin E and CP (group 2), estradiol plus vitamin C and CP (group 3), and estradiol plus losartan and CP (group 4), respectively. The star indicates significant difference () when compared with the positive control group.
