Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model

Table 2

The mortality rate of animals in each group during the second week of the experiment.

Group	N	Day							n
		1	2	3	4	5	6	7
Number 1: estradiol + CP	6	—	—	—	—	—	—	—	6
Number 2: estradiol + CP + vitamin E	7	—	—	—	—	—	—	—	7
Number 3: estradiol + CP + vitamin C	7	—	—	—	—	1	2	1	3
Number 4: estradiol + CP + losartan	7	—	—	—	—	1	1	2	3
Number 5: CP + vehicle (positive control)	5	—	—	—	—	—	—	—	5
Number 6: estradiol + vehicle (negative control)	5	—	—	—	—	—	—	—	5
Number 7: vehicle (negative control)	5	—	—	—	—	—	—	—	5

N: total number of animals at the beginning of experiment. All animals were ovariectomized, n: number of animals at the end of the experiment, CP: cisplatin. CP was administered at the beginning of the second week.